The European Network of Excellence for Biomedical Data Mining and Semantic Interoperability aims at bridging gaps in European research infrastructure and facilitating cross-fertilisation between scientific disciplines such as computer science, system engineering and medical/clinical research. The long-term goal of the network is the development of generic methods and tools supporting critical tasks in medical and biomedical informatics, such as, data-mining, knowledge discovery, knowledge representation, abstraction and indexing of information, semantic-based information retrieval in a complex and high-dimensional information space, and knowledge based adaptive systems for provision of decision support for dissemination of evidence based medicine.